LNME.AO

Pirazinamida

Prescription Hospital MunicipalHospital Geral e/ou Especializado

Overview

National code
28-15008RS
UNSPSC
51281504
Composition
400 mg
Presentation
comprimido
Prescription
Required
Levels of care
Hospital Municipal, Hospital Geral e/ou Especializado
ATC code
J04AK01

Dose calculator

Estimate from the rules recorded for this medicine. Always confirm before prescribing.

⚠️ The calculator is an aid: always confirm the dose against your local clinical protocol. Rules marked “pending review” have not yet been validated by a pharmacist or doctor.

Safety and references

  • The result is a calculation aid, not a prescription: check it against the leaflet, the local protocol or a pharmacist.
  • Obese patients: a per-kg dose may call for ideal or adjusted weight, not actual weight.
  • Renal or hepatic impairment may require adjusting the dose or the interval.
  • Chemotherapy and other narrow-margin drugs only with a specialist.
  • Check the units (mg or mcg, IU, ml) and that the weight is plausible before giving the drug.

References

  1. Bates DW, et al. Incidence of adverse drug events and potential adverse drug events. JAMA. 1995;274(1):29-34.
  2. Merry AF, Anderson BJ. Medication errors — new approaches to prevention. Paediatr Anaesth. 2011;21(7):743-753.

Interactions

  • Moderada Alopurinol

    Clinical effect: A pirazinamida aumenta o ácido úrico e reduz o efeito do alopurinol.

    Recommendation: Vigiar o ácido úrico e os sintomas de gota durante o tratamento da tuberculose.

    Source: BNF

  • Moderada Isoniazida

    Clinical effect: A associação aumenta o risco de hepatotoxicidade.

    Recommendation: Vigiar os sintomas e as enzimas hepáticas, sobretudo nos primeiros dois meses.

    Source: OMS: tratamento da tuberculose

⚠️ The drug-interaction analysis in LNME.AO is for information only and does not replace clinical or pharmaceutical validation by a professional.

Check against other medicines