LNME.AO

Quinina

Prescription Centro de SaúdeHospital MunicipalHospital Geral e/ou Especializado

Overview

National code
10-19009RS
UNSPSC
51101904
Composition
300 mg (sulfato) ou 300 mg (bissulfato)
Presentation
comprimido
Prescription
Required
Levels of care
Centro de Saúde, Hospital Municipal, Hospital Geral e/ou Especializado
ATC code
P01BC01

Dose calculator

Estimate from the rules recorded for this medicine. Always confirm before prescribing.

⚠️ The calculator is an aid: always confirm the dose against your local clinical protocol. Rules marked “pending review” have not yet been validated by a pharmacist or doctor.

Safety and references

  • The result is a calculation aid, not a prescription: check it against the leaflet, the local protocol or a pharmacist.
  • Obese patients: a per-kg dose may call for ideal or adjusted weight, not actual weight.
  • Renal or hepatic impairment may require adjusting the dose or the interval.
  • Chemotherapy and other narrow-margin drugs only with a specialist.
  • Check the units (mg or mcg, IU, ml) and that the weight is plausible before giving the drug.

References

  1. Bates DW, et al. Incidence of adverse drug events and potential adverse drug events. JAMA. 1995;274(1):29-34.
  2. Merry AF, Anderson BJ. Medication errors — new approaches to prevention. Paediatr Anaesth. 2011;21(7):743-753.

Interactions

  • Grave Moxifloxacina

    Clinical effect: Aumenta o risco de prolongamento do intervalo QT e de arritmias graves.

    Recommendation: Evitar. Se for essencial, monitorizar o ECG e os eletrólitos.

    Source: BNF

  • Grave Rifampicina

    Clinical effect: A rifampicina reduz muito os níveis de quinina, com risco de falha no tratamento da malária.

    Recommendation: Evitar. Escolher outro esquema antimalárico.

    Source: OMS: tratamento da malária / BNF

  • Grave Haloperidol

    Clinical effect: Risco aumentado de prolongamento do QT e arritmias.

    Recommendation: Monitorizar ECG. Evitar combinação.

    Source: BNF

  • Grave Amiodarona

    Clinical effect: Ambos prolongam o QT e têm efeitos antiarrítmicos que se somam perigosamente.

    Recommendation: Contraindicado. Monitorizar ECG se inevitável.

    Source: ESC Guidelines / BNF

  • Moderada Ondansetron

    Clinical effect: Aumenta o risco de prolongamento do intervalo QT.

    Recommendation: Monitorizar o ECG e corrigir os eletrólitos.

    Source: BNF

  • Moderada Lumefantrina

    Clinical effect: Aumenta o risco de prolongamento do intervalo QT.

    Recommendation: Monitorizar o ECG, sobretudo se a quinina for dada nos dias seguintes à lumefantrina.

    Source: OMS: tratamento da malária

  • Moderada Ritonavir

    Clinical effect: O ritonavir aumenta as concentrações de quinina.

    Recommendation: Vigiar o ECG e sinais de cinchonismo.

    Source: Liverpool HIV Drug Interactions

  • Moderada Cloroquina

    Clinical effect: Aumenta o risco de prolongamento do intervalo QT e de convulsões.

    Recommendation: Evitar. Se for essencial, monitorizar o ECG.

    Source: BNF

  • Moderada Fenobarbital

    Clinical effect: O fenobarbital reduz as concentrações de quinina.

    Recommendation: Vigiar a resposta antimalárica.

    Source: BNF

  • Moderada Fenitoína

    Clinical effect: A fenitoína reduz as concentrações de quinina.

    Recommendation: Vigiar a resposta antimalárica.

    Source: BNF

  • Moderada Carbamazepina

    Clinical effect: A carbamazepina reduz as concentrações de quinina e a quinina aumenta as de carbamazepina.

    Recommendation: Vigiar a resposta antimalárica e sinais de toxicidade.

    Source: BNF

  • Moderada Digoxina

    Clinical effect: A quinina aumenta as concentrações de digoxina.

    Recommendation: Vigiar as concentrações de digoxina e sinais de toxicidade.

    Source: BNF

⚠️ The drug-interaction analysis in LNME.AO is for information only and does not replace clinical or pharmaceutical validation by a professional.

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